Plain-English translation of NCT05858437 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether propionic acid, a naturally occurring compound, can help reduce chronic inflammation in children with advanced kidney disease who receive dialysis. The study is based on research showing that children on dialysis have low levels of propionic acid in their blood, and that increasing this level might help their immune system fight harmful inflammation.
Children with advanced kidney disease have ongoing inflammation that increases their risk of heart disease and other serious complications. This medication may help by working with the body's natural immune cells to reduce this harmful inflammation.
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If you enroll, you will be randomly assigned to take either the propionic acid supplement or a placebo (a dummy pill with no active ingredient) twice daily for 28 days. Both look the same, so you won't know which one you're taking. During this month, the research team will monitor your health and take blood samples to measure changes in your immune system and inflammation levels.
AI-generated summary from trial data · Jul 2, 2026 · Not medical advice
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