Plain-English translation of NCT05858632 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This research study is testing how , an FDA-approved medication for psoriasis, works at the cellular level in scalp psoriasis lesions. Researchers want to understand exactly how the medication changes the immune cells in your skin that are causing psoriasis. By learning more about this, scientists hope to better understand and improve treatments for scalp psoriasis.
is already proven to help psoriasis, but doctors want to understand the detailed mechanics of how it actually works—specifically what happens to immune cells in the skin. This knowledge could lead to better treatments or help predict which patients will respond best to this medication.
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You would receive treatment for approximately 9 months. During this time, researchers will take small skin samples (biopsies) from your scalp lesions at specific visits to examine how your immune cells are changing. These samples will be analyzed in the lab to understand how your body is responding to the medication. The study involves a small group of 10 participants total.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
University of California, San Francisco
Collaborators
Janssen Scientific Affairs, LLC
Enrollment target
~10 participants
Started
July 2023
Primary completion
June 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in June 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jeffrey Cheng, MD, PhD
University of California, San Francisco
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.