Plain-English translation of NCT05867381 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a special high-efficiency air filter (called a HEPA filter) installed in your home can help slow the progression of atherosclerosis—a condition where plaque builds up in your arteries and worsens heart disease. The study involves 112 older adults with a history of heart disease, and researchers will monitor how your heart and blood vessels respond to cleaner indoor air over 21 months.
Air pollution is known to harm people with heart disease, but most treatments focus on outdoor air. This research wants to see if improving the air quality inside your home—where you spend much of your time—can actually help protect your heart and slow disease progression.
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You will be randomly assigned to use either a real HEPA air filter or a sham filter (one that looks the same but doesn't actually filter) for 9 months, then switch to the other type after a 3-month break. Research staff will visit your home three times during each 9-month period to set up equipment, check your blood pressure, measure how well your blood vessels are working, collect blood samples, and ask health questions. You'll also check your own blood pressure daily at home. The entire study lasts 21 months.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States
Sponsor
University of Southern California
Collaborators
Duke University, National Institute of Environmental Health Sciences (NIEHS)
Enrollment target
~112 participants
Started
July 2023
Primary completion
June 2028
Age range
65 Years – 84 Years
Last updated on clinicaltrials.gov in June 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Zhanghua Chen, PhD
University of Southern California
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.