Testing two treatments together for aggressive lymphoma that developed from chronic leukemia

Plain-English translation of NCT05873712 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated August 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a combination of two medications for Richter's syndrome, a serious condition where an aggressive lymphoma develops in people who have chronic lymphocytic leukemia (CLL). The first medication is , a pill you take twice daily. The second is , which is a type of cell therapy—your own immune cells are collected, specially trained in the laboratory to fight cancer, and then returned to your body through an infusion.

Richter's syndrome is very difficult to treat, especially when the cancer comes back or doesn't respond to earlier treatments. Doctors are testing whether combining this targeted pill with this specialized cell therapy might be more effective than treatments used in the past.

Do you qualify?

You likely qualify if…

you have been diagnosed with Richter's syndrome (an aggressive lymphoma that developed from chronic lymphocytic leukemia)
your disease has come back or stopped responding to at least one prior treatment
you are 18 years or older
you are healthy enough to tolerate this intensive treatment (good heart, liver, and kidney function)
you are willing to have blood tests, biopsies, and imaging scans throughout the study

You likely don't qualify if…

you have severely impaired liver or kidney function
your heart is not strong enough (left ventricular ejection fraction below 40%)
you have very low blood cell counts that cannot be explained by your disease
you are pregnant or unwilling to use contraception during the study

What participation looks like

You will start by taking the pill medication twice daily for up to 90 days. About two weeks after starting, your immune cells will be collected through a process called leukapheresis (like a blood donation but the cells are returned to you). You will then receive chemotherapy medicines followed by an infusion of your engineered cells. Throughout the study, you will have blood tests, biopsies, and imaging scans to monitor how well the treatment is working and watch for side effects. After the initial treatment phase, you will be followed closely for 24 months, then every 6 months to see how long the treatment continues to work.

Testing two treatments together for aggressive lymphoma that developed from chronic leukemia

What is this trial?

Do you qualify?

What participation looks like

Trial locations(3 sites)