Recruiting

Testing a new heart pump device for advanced heart failure

Plain-English translation of NCT05876000 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing the Corheart 6 Left Ventricular Assist System, a mechanical pump that is surgically implanted to help your heart pump blood more effectively. The study will enroll about 53 people across multiple European hospitals to see whether this treatment is safe and works well in patients with advanced heart failure that hasn't responded to standard medical care. Researchers will follow participants for at least 6 months after implantation to see how well the device performs.

For some people with very severe heart failure, standard medications and treatments are not enough to keep them alive or improve their quality of life. This trial exists to find out whether this new mechanical pump device can help patients who have exhausted other treatment options, potentially improving their survival and allowing them to live more active lives.

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you have been diagnosed with severe heart failure (NYHA Class IV) despite taking the best available medications
your heart's pumping function is severely reduced (left ventricular ejection fraction of 25% or lower)
you meet at least one of: you cannot exercise due to heart failure, you have shown progressive organ damage, you are currently on a temporary heart support device, or you are dependent on intravenous medications to keep your heart working
your body size is adequate for the device (body surface area of at least 1.2 m²)

You likely don't qualify if…

you have bleeding disorders, clotting problems, or very low platelet counts that would make blood-thinning medications unsafe
you cannot or will not take the blood-thinning and other medications required after device implantation
you have severe lung disease, advanced liver disease, recent stroke, or severe kidney problems
you have a severe untreated infection or psychiatric conditions that would prevent you from reliably managing the device
your heart failure is caused by conditions that can be treated with other procedures or devices, such as heart rhythm therapy

What participation looks like

If you are selected for this study, you will undergo surgery to have the Corheart 6 pump implanted in your body to assist your heart's pumping function. After surgery, you will have regular follow-up visits with the research team to monitor how well the device is working, check for any complications, and assess how you are feeling and functioning. The study will track your health and safety for at least 6 months after implantation, with the goal of gathering long-term information about how the device performs over time.

AI-generated summary from trial data · Aug 12, 2026 · Not medical advice

Trial locations(11 sites)

Austria

Universitätsklinikum Graz, Graz

Universitätskliniken der MedUni Wien, Vienna

Germany

Herz-und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen

Deutsches Herzzentrum der Charité, Berlin

Klinikum Links der Weser, Bremen