Plain-English translation of NCT05879432 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a medication called to see if it can prevent or reduce kidney damage that sometimes happens after heart surgery. Kidney damage after surgery is a serious complication, especially for people who already have some kidney disease or other risk factors. This study will compare the medication to a placebo (a fake treatment with no active drug) to find out if it actually works.
Heart surgery that uses a heart-lung machine can sometimes damage the kidneys, especially in patients who are already at higher risk. There is currently no proven way to prevent this kind of kidney injury, so researchers are testing whether this new medication might help protect the kidneys during and after surgery.
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If you join, you will receive either the new medication or a placebo by IV injection twice a day for 5 days, starting before your surgery. You will have blood and urine tests on multiple days to monitor how well your kidneys are working. You will also have physical exams and vital signs checked daily during treatment and then again on Days 6, 7, and 28 after your surgery. The entire study lasts about 4 weeks of follow-up care.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
Canada
Turkey (Türkiye)