Plain-English translation of NCT05886517 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a minimally invasive procedure called transcatheter aortic valve implantation (TAVI) for patients with severe narrowing of the aortic heart valve who cannot safely undergo traditional open-heart surgery. Instead of opening the chest, doctors insert a new valve through a catheter in the groin and guide it to the heart. The study will follow about 200 patients to see how safe and effective this procedure is when performed in hospitals that don't have cardiac surgery available on-site.
Many elderly and very frail patients with severe aortic valve disease cannot have traditional surgery because of their age, overall health, or other serious medical conditions. This trial exists to see whether the minimally invasive catheter-based approach can safely and effectively treat these high-risk patients at hospitals without immediate access to surgical backup.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will be evaluated beforehand to make sure you are eligible and safe for the procedure. On the day of the procedure, you will receive standard preparation for the minimally invasive catheter-based implant. After the procedure, you will stay in the hospital for monitoring and standard post-procedure care. You will return for a follow-up visit 30 days after the procedure so doctors can check on your recovery, confirm the valve is working well, and watch for any complications.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Italy
Spain