Plain-English translation of NCT05892510 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
When someone has a large stroke caused by a blood clot in the brain, doctors perform emergency surgery to remove the clot. This trial is testing whether giving an additional medication called tenecteplase directly into the artery during that surgery can help dissolve any remaining clot material and improve blood flow. The medication is delivered through a tiny tube while the surgeon is already treating the stroke.
After emergency clot-removal surgery, some patients still have bits of clot remaining or poor blood flow in the brain, which can limit how well they recover. Researchers want to know if giving this medication at that critical moment—while doctors are already in the artery—can prevent these complications and lead to better outcomes.
You likely qualify if…
You likely don't qualify if…
If you qualify and agree to join, you will receive emergency stroke surgery as planned. During that surgery, you will randomly receive either the study medication or a placebo (a saline solution with no medication) injected directly into the artery where the clot was. You won't know which one you received. After surgery, the research team will follow your recovery with imaging scans and regular check-ins to see how well you're doing compared to the other group.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
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