Plain-English translation of NCT05896592 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial compares two approaches for patients under 65 who had pacemakers implanted for an abnormally slow heartbeat. Some participants will receive a procedure called cardioneuroablation—which targets nerve fibers controlling heart rhythm—along with continued pacemaker support and an implanted heart monitor. Others will receive standard pacemaker therapy with an implanted monitor. The goal is to see if the nerve ablation procedure can reduce or eliminate the need for pacemaker pacing over time.
Many younger patients with slow heartbeats rely heavily on pacemakers, which require long-term device management and battery replacements. Researchers believe that by ablating (disabling) specific nerve fibers that contribute to slow heart rhythms, some patients might regain their own normal heart rhythm and eventually need little or no pacemaker support—improving quality of life and reducing lifetime treatment burden.
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You will be randomly assigned to one of three groups over about 7 months of active monitoring, followed by a year of follow-up visits. Some participants will undergo two specialized heart procedures (electrophysiology study and nerve ablation), have their pacemaker settings adjusted multiple times, and receive an implanted heart monitor. Others will receive adjusted pacemaker settings and the implanted monitor without the ablation procedure. All participants will attend regular clinic visits (at 3, 6, and 12 months) for heart rhythm checks, electrocardiograms, and symptom assessments. The trial will assess whether the ablation approach allows some patients to eventually reduce or eliminate their pacemaker dependence.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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