Plain-English translation of NCT05898269 on ClinicalTrials.gov ↗ ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing four different quick bedside maneuvers to help doctors predict whether patients with severe acute respiratory distress syndrome (ARDS) who are lying face-down will benefit from extra fluids. Doctors need to know which patients truly need more fluid versus which ones might get worse from it. This study will compare how accurate each of the four tests is at making that prediction.
Patients with severe ARDS who are very sick often need extra fluids, but giving too much fluid can actually make their breathing worse and lead to worse outcomes. Most existing tests to predict fluid needs can only be done when patients are lying on their backs, but these patients must lie face-down most of the day to help them breathe. Doctors need new ways to safely predict fluid needs while patients are in this position.
You likely qualify if…
You likely don't qualify if…
You will remain lying face-down in your hospital bed while attached to standard monitoring equipment. Your medical team will perform four different quick tests in random order, with short breaks between each one to let your body return to normal. Each test involves temporary changes to your breathing or gentle body positioning lasting just minutes. After all four tests are completed, you will receive a standard 500-milliliter fluid bolus (extra IV fluid), and your heart's response will be measured to determine which test was most accurate.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
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