Plain-English translation of NCT05907694 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a minimally invasive procedure to close a patent foramen ovale—a small opening in the heart—can prevent another stroke better than taking heart-protective medications alone. You'll be randomly assigned to either receive the closing procedure plus medication, or medication by itself. The study focuses on people over 60 who have experienced an unexplained stroke and have this heart opening.
Younger patients with unexplained strokes and this heart opening have benefited from the closing procedure, but doctors need solid evidence that it works just as well—or even better—in older patients. This trial will provide that evidence to help guide treatment decisions.
You likely qualify if…
You likely don't qualify if…
If you qualify, you'll be randomly assigned to one of two groups: one group will undergo a catheter-based procedure to close the heart opening plus receive stroke-prevention medications, while the other group will receive medications alone. You'll visit the clinic for heart imaging tests (echocardiograms) and monitoring appointments, and researchers will track you for any future strokes or health events over time. Your doctor will manage your blood pressure, cholesterol, and other stroke risk factors according to standard guidelines.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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