Plain-English translation of NCT05908760 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a CO2 rebreathing device—a simple tool that captures the air you breathe out and lets you breathe it back in—to see if it can help raise blood pressure in people with neurogenic orthostatic hypotension. When you have this condition, your blood pressure drops dangerously when you stand up, often causing dizziness, fainting, and a greatly reduced quality of life. The researchers believe that increasing carbon dioxide in your blood through this rebreathing device may help your body naturally raise your blood pressure and help you tolerate standing better.
Neurogenic orthostatic hypotension is a serious condition that makes everyday activities difficult and increases your risk of heart problems. Current treatment options are limited, so researchers are exploring whether this breathing device—which is simple, affordable, and uses your body's own natural processes—could offer a new way to help manage sudden blood pressure drops when standing.
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You would visit the University of Calgary's Autonomic Testing Lab for one session. First, you'll lie down and breathe either through the rebreathing device or normal room air (decided randomly) until your carbon dioxide levels increase slightly. Then, you'll be tilted upright while continuing to breathe through whichever device you were assigned, and researchers will monitor your blood pressure and how you feel for 5 minutes. The study aims to understand whether the rebreathing device helps your body maintain better blood pressure when standing.
AI-generated summary from trial data · Oct 7, 2026 · Not medical advice
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