Plain-English translation of NCT05910866 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Some patients who receive permanent pacemakers develop a weakening of the heart muscle over time, called pacing-induced cardiomyopathy. This trial is testing a newer way to place the pacemaker lead — called left bundle branch area pacing — to see if it can prevent this heart weakening better than the traditional pacemaker placement method.
Standard pacemakers can sometimes cause the heart to weaken over years, leading to heart failure symptoms and hospitalizations. This trial exists to see if a newer lead placement technique can protect your heart from this side effect while still providing the pacing you need.
If you enroll, you will be randomly assigned to receive a pacemaker with either the new lead placement technique or the standard placement technique. You will then have regular follow-up visits where your doctors will check how well your heart is working using heart imaging tests and other measurements. The trial will track your heart health over time to see if the new placement technique helps prevent heart weakening.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
Italy
Sponsor
Azienda Ospedaliero Universitaria Maggiore della Carita
Enrollment target
~130 participants
Started
June 2023
Primary completion
June 2025
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Gabriele Dell'Era, MD
Azienda Ospedaliero Universitaria Maggiore della Carita