Plain-English translation of NCT05913960 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing a newer form of magnetic brain stimulation called accelerated intermittent theta-burst stimulation (aiTBS) to see if it can treat major depression faster and more effectively than older methods. Researchers believe this treatment works by changing how certain brain chemicals and circuits function, particularly in the parts of your brain responsible for mood. The trial will compare this new approach to fake stimulation and traditional faster magnetic stimulation.
Regular depression treatments can take weeks or months to work, and some people don't respond to them at all. Researchers developed this faster version of magnetic stimulation to see if it can help people feel better more quickly and understand exactly how it works in the brain.
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You will visit the hospital for 5 consecutive days to receive magnetic stimulation sessions. Each day, you will receive 10 treatment sessions spaced 50 minutes apart, with each session lasting just 2 seconds but delivering magnetic pulses to a specific area of your brain. Before and after treatment, researchers will do brain scans and monitor your brain activity. The study will track your mood and depression symptoms throughout the process to see how you respond.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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