Plain-English translation of NCT05914649 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether normal saline (salt water) given through an IV can help improve brain fog and cognitive problems in people with Long COVID or POTS. Researchers will measure your thinking skills using computer tests before and after you receive the salt water infusion. Some participants will receive a larger dose (999 mL) and some a smaller dose (50 mL) to see if the larger amount works better.
Many people with Long COVID and POTS report significant brain fog and memory problems that make it hard to work or study. There is very limited research on whether this medication can help with these cognitive symptoms, so this pilot study is an important first step to understand the problem and explore a potential treatment.
You likely qualify if…
You likely don't qualify if…
You will come to a study visit where a trained staff member will place an IV line in your arm and give you either a larger or smaller amount of salt water infusion (this takes up to 30 minutes). You will then lie down while your heart rhythm and blood pressure are monitored. After that, you will complete computer-based tests that measure your thinking skills, memory, and concentration. This is a crossover study, meaning you may come back for a second visit to receive the other dose so researchers can compare how each amount affects your cognition.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Canada
Sponsor
University of Calgary
Enrollment target
~100 participants
Started
September 2024
Primary completion
December 2030
Age range
18 Years – 60 Years
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Satish R Raj, MD MSCI
University of Calgary
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.