Plain-English translation of NCT05917587 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This research study is testing whether metformin—a common diabetes medication—can help improve how blood vessels work in women who experienced gestational diabetes during pregnancy. Women with a history of gestational diabetes have a higher risk of heart disease later in life, even after their blood sugar returns to normal. Researchers want to understand why this happens and whether the medication can prevent or reduce this risk.
Women who had gestational diabetes face double the risk of developing heart disease in the years after pregnancy, but doctors don't fully understand why their blood vessels remain damaged even after their diabetes goes away. This study aims to find out what's causing the problem and whether this medication could help prevent serious heart disease before it starts.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to receive either metformin or a placebo (a pill with no active medication). Researchers will examine how your skin blood vessels respond to heat using a small, painless procedure where they place tiny tubes on your skin and gently warm the area. They will also take a blood sample to look at inflammation-related cells. The study involves a small number of visits to assess how the medication affects your blood vessel function.
AI-generated summary from trial data · Aug 22, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Anna Stanhewicz, PhD
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~30 participants
Started
September 2024
Primary completion
December 2027
Age range
18 Years – 45 Years
Sex
Female only
Last updated on clinicaltrials.gov in October 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Anna Stanhewicz, PhD
University of Iowa
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.