MRI scans to predict radiation therapy response in head and neck cancer

Plain-English translation of NCT05919290 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether special MRI imaging scans taken during radiation therapy can predict how well the treatment is working and help doctors personalize care for patients with head and neck cancer. Researchers want to understand which imaging patterns show early response to treatment, so doctors can adjust therapy if needed to improve outcomes and reduce side effects.

Radiation therapy is an important treatment for head and neck cancer, but some patients experience treatment failure or long-term side effects even though the treatment is effective overall. This trial exists to find imaging biomarkers that can identify early on how individual patients are responding, so doctors can personalize therapy and potentially improve results.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with head and neck squamous cell carcinoma that is at least 3 centimeters in size
you are planned to receive radiation therapy (with or without chemotherapy) as your main cancer treatment
you are willing and able to undergo multiple MRI scans during and after your treatment
you have adequate kidney function (your doctor can check this with a blood test)

You likely don't qualify if…

you have had another solid tumor treated within the past 5 years
you are pregnant or may become pregnant
you have a serious history of airway obstruction or severe breathing problems
you have a contraindication for MRI scans (such as certain metal implants or a gadolinium contrast allergy)
you cannot lie comfortably on your back for about one hour

What participation looks like

If you join this study, you will receive MRI scans (a type of imaging test) once weekly during your radiation therapy treatment, plus additional scans at baseline and 6-8 weeks after treatment ends. The MRI scans use no radiation and no contrast dye, and each scan takes about an hour. Your participation helps researchers understand which imaging patterns predict treatment response and side effects, which could help personalize cancer care in the future.

AI-generated summary from trial data · Jun 10, 2026 · Not medical advice

Trial locations(1 site)

Canada

Princess Margaret Cancer Centre, Toronto, Ontario