Plain-English translation of NCT05923801 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing electroconvulsive therapy (ECT) — a medical procedure that uses controlled electrical stimulation to help severe depression — in people who haven't responded well to their initial treatment. The study compares two placement strategies for the electrodes: one that has traditionally caused fewer memory side effects, and one that may work faster. Researchers want to see which approach helps people recover better while protecting their memory.
Some people with severe depression don't respond to regular medications or other treatments. This trial exists to figure out whether changing where the electrodes are placed during treatment — if the first approach isn't working — can speed up recovery and reduce memory problems.
You likely qualify if…
You likely don't qualify if…
If you qualify, you'll receive ECT treatment sessions and be randomly assigned to either continue with your current electrode placement or switch to a different one. You'll have assessments of your mood and thinking ability at several timepoints: before randomization, after 8 sessions, at the end of the acute treatment course, and again three months later. The study follows you throughout your active treatment and for three months afterward to track how well you improve and how the treatment affects your memory and thinking.
AI-generated summary from trial data · Jul 19, 2026 · Not medical advice
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