Testing frozen gloves and socks to prevent nerve damage from breast cancer chemotherapy

This trial is testing whether wearing special glycerine-filled frozen gloves and socks during paclitaxel chemotherapy can prevent a common side effect called peripheral neuropathy—a condition where patients experience numbness, tingling, and nerve pain in their hands and feet. About half of participants will wear the frozen gloves and socks during their chemotherapy infusions, while the other half will receive chemotherapy without this intervention. The study will measure how many people develop nerve damage and how severe it is.

Paclitaxel is an effective chemotherapy drug for breast cancer, but it frequently causes nerve damage that can be painful and long-lasting. Currently, there is no proven way to prevent this side effect, so researchers are testing whether keeping hands and feet cold during treatment might reduce the risk of nerve damage.