Plain-English translation of NCT05928936 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
People with chronic kidney disease often feel very tired during exercise and can't exercise for very long. This study is testing whether —a common supplement that reduces acidity in the body—combined with regular exercise training can help improve your ability to exercise and build physical fitness. Researchers believe that kidney disease may affect how your blood vessels and nerves control blood flow during exercise, and this medication might help correct that problem.
Doctors don't fully understand why people with kidney disease struggle so much with exercise. This trial is trying to figure out if abnormal responses in blood vessels and nerve signals during exercise are the main cause, and whether this medication can help fix that and make exercise easier and safer.
You likely qualify if…
You likely don't qualify if…
You will visit the research center multiple times for baseline tests and then complete 12 weeks of exercise training on a stationary bike for 20–45 minutes, three times per week. Half of participants will take tablets twice daily, and the other half will take identical-looking placebo tablets. The researchers will measure your exercise capacity, blood pressure response, and blood flow before and after the training program.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
Emory University
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~156 participants
Started
November 2022
Primary completion
June 2028
Age range
40 Years – 75 Years
Last updated on clinicaltrials.gov in October 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Dana DaCosta
Emory University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.