Plain-English translation of NCT05929612 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Lymphoma research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new approach using ultra-low dose radiation therapy to treat marginal zone lymphoma, a slow-growing blood cancer. The treatment uses a very small amount of radiation (4 Gray, with an optional additional 12 Gray if needed) delivered over just 1-2 days. Researchers want to see if this minimal radiation dose can work just as well as standard treatments while reducing side effects.
Current treatments for marginal zone lymphoma often use chemotherapy or higher radiation doses, which can cause significant side effects. This trial exists to find out whether using much lower radiation doses might be effective and safer for patients.
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You will receive very low dose radiation therapy over 1-2 days as your main cancer treatment. Researchers will follow you over 24 months to see how well the treatment worked, checking for cancer recurrence and overall health. You may also be asked to provide optional blood samples and stool samples so researchers can study how your body's microbiome (bacteria) might predict who responds best to this treatment.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
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