Plain-English translation of NCT05935605 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are studying whether ultrasound imaging of the heart can accurately measure high blood pressure in the lungs (called pulmonary hypertension) in patients with left heart disease. The study compares these ultrasound measurements with direct pressure readings taken during a standard heart catheterization procedure — a test many of these patients already need for their heart condition.
Many patients with left heart disease develop dangerous increases in lung blood pressure, but doctors don't always have reliable, non-invasive ways to detect and measure this problem early. This study aims to determine whether ultrasound and breathing tests can help doctors diagnose and understand lung blood pressure problems without always needing an invasive catheterization procedure.
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If you enroll, you'll come for a heart catheterization procedure that your doctor has already recommended. During this visit, you'll also receive an ultrasound of your heart and lungs, provide blood samples, and perform a breathing exercise test while doctors measure your oxygen and carbon dioxide levels. The study compares how these non-invasive measurements match up with the direct pressure readings obtained during the catheterization itself, helping doctors understand whether ultrasound alone could be used to monitor lung blood pressure in the future.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~3,000 participants
Started
July 2023
Primary completion
May 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
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Central contact
Circulatory Failure Research Team
Mayo Clinic
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