Plain-English translation of NCT05938543 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study tests whether a noninvasive technique called transcranial magnetic stimulation (TMS) can help reduce excessive hunger in people with Prader-Willi syndrome. TMS uses a magnetic coil held against your scalp to gently stimulate a part of your brain called the cerebellum. Researchers believe this stimulation might help improve the brain's natural feelings of fullness and reduce the constant urge to eat that characterizes this condition.
People with Prader-Willi syndrome experience severe, uncontrolled hunger that's very difficult to manage with diet and behavior changes alone. This study is exploring whether this new treatment approach could offer a way to help regulate hunger signals in the brain.
You likely qualify if…
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If you join this study, you would receive transcranial magnetic stimulation once per day for one week. The treatment involves sitting comfortably while a magnetic coil is held against your scalp — it's noninvasive and doesn't require any injections or surgery. You would also likely have brain imaging scans to help researchers understand how the treatment affects your brain's hunger signals.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States
Brigham and Women's Hospital
Collaborators
Foundation for Prader-Willi Research
Enrollment target
~20 participants
Started
September 2023
Primary completion
September 2026
Age range
18 Years – 64 Years
Last updated on clinicaltrials.gov in December 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Laura Holsen, PhD
Brigham and Women's Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.