Plain-English translation of NCT05939687 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether using a polypropylene mesh—a thin, flexible material—during surgery to close a temporary bowel opening (stoma) can prevent painful hernias from developing later. Half of the 142 participants will receive the mesh as part of their closure surgery, while the other half will have their stoma closed using traditional stitching alone. The study will track both groups for 2 years to see if the mesh significantly reduces hernia rates.
After temporary stoma closure surgery, hernias (bulges in the abdominal wall) develop in about 30% of patients and can cause pain, infection, and require repeat surgery. Researchers believe adding the mesh during initial closure might prevent these hernias from forming, improving long-term quality of life.
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If you enroll, you will be randomly assigned to either have your stoma closed with mesh reinforcement or with standard stitching alone. Your stoma closure surgery will proceed as planned, with the only difference being whether the mesh is added. After surgery, you will have regular follow-up visits over 2 years, including physical exams and quality-of-life surveys to check for hernias and assess how you're doing.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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