Plain-English translation of NCT05942287 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Heart Failure research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether losing weight can help people whose hearts don't pump as well as they should. About half of participants will follow a supervised 8-week meal replacement diet designed to help them lose weight safely, while the other half will continue their usual care. The study will measure whether weight loss improves how the heart works and how much participants can exercise.
Doctors have noticed that weight loss sometimes helps heart failure patients, but they want to understand exactly how and why this works. This treatment will help answer whether a structured weight loss program can actually improve heart function and quality of life.
You likely qualify if…
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You'll have two study visits about 3–6 months apart. At each visit, you'll complete heart imaging (ultrasound and MRI scans), blood tests, a 6-minute walking test, and questionnaires about your symptoms and quality of life. If you're randomly chosen for the diet group, you'll follow a supervised 8-week meal replacement program using formula soups, shakes, and porridges, followed by a guided transition back to regular food. If you're in the standard care group, you'll continue your usual heart failure treatment.
AI-generated summary from trial data · Jul 19, 2026 · Not medical advice
Jersey
United Kingdom