Plain-English translation of NCT05945043 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is investigating how draining fluid from around your lungs (called a pleural effusion) affects your breathing and the signals your brain sends to your breathing muscles. Researchers will measure your breathlessness, breathing muscle activity, and brain electrical signals before and after the fluid is removed to better understand how the treatment helps you breathe easier.
Fluid around the lungs makes it hard to breathe, and doctors drain it to help patients feel better. This study wants to understand exactly how removing this fluid improves breathing by measuring the signals that control your breathing muscles.
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You will visit a UK clinic over an 18-month recruitment period. When you come to have your lung fluid drained, researchers will take measurements of your breathing, breathing muscle activity, and brain signals before the procedure, immediately after, and then again at 1 day and 7 days later. The whole study involves standard clinical care you would receive anyway, with added monitoring to track how your breathing improves.
AI-generated summary from trial data · Oct 12, 2026 · Not medical advice
United Kingdom
Guy's and St Thomas' NHS Foundation Trust
Enrollment target
~124 participants
Started
November 2023
Primary completion
June 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in June 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Junyi Zhang, MBBChir
Guy's and St Thomas' NHS Foundation Trust
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.