Recruiting

Tissue Flap Surgery to Improve Brain Tumor Treatment

Plain-English translation of NCT05954858 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

Glioblastoma is a serious type of brain cancer with poor survival rates even with standard treatment. This trial is testing whether surgeons can improve outcomes by placing a special tissue flap—taken from your own scalp—into the cavity left after removing the tumor. The tissue flap is designed to help deliver treatment more effectively to the tumor area.

Even with surgery, chemotherapy, and radiation, most glioblastoma patients only survive about 15 months. The brain has a natural barrier that blocks many treatments from reaching tumor cells. This study explores whether the tissue flap can help bypass that barrier and give patients better results.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with or are suspected of having glioblastoma
you are well enough to undergo surgery (your doctor rates you at 70% or higher on a standard health scale)
your surgeon believes they can remove at least 80% of the visible tumor
you are able to have MRI scans during the study
your blood counts and organ function are healthy enough for surgery

You likely don't qualify if…

you are pregnant or breastfeeding
you have already started chemotherapy or radiation for this tumor
you have signs that the cancer has spread to multiple areas of the brain or along the spinal fluid
you have a current infection that needs treatment
you have HIV or active hepatitis B or C infections

What participation looks like

You will have surgery to remove your brain tumor, and during that same surgery, your surgeon will place a tissue flap (harvested from your own scalp area) into the cavity where the tumor was removed. After surgery, you will have follow-up visits at 3 days, 1 week, 1 month, 2 months, 4 months, and 6 months to check for side effects and monitor how well the treatment is working. Researchers will track whether the tumor comes back and how long you survive.

AI-generated summary from trial data · Jun 4, 2026 · Not medical advice

Trial locations(1 site)

United States

Lenox Hill Brain Tumor Center, New York, New York