Plain-English translation of NCT05958706 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Heart Failure research guide →Researchers know that type 2 diabetes significantly increases the risk of heart failure and heart damage, but they don't fully understand exactly why or how it happens. This study collects small samples of heart tissue from people undergoing heart biopsies or transplants—with or without diabetes—to study how the heart's energy-producing structures (called mitochondria) work differently in diabetic patients. Understanding these differences could help doctors catch and treat diabetes-related heart problems much earlier.
People with type 2 diabetes are at much higher risk of dying from heart disease, yet doctors don't have good tools to predict or prevent this. The treatment appears to damage the heart's cellular power plants in ways scientists don't fully understand. By studying real heart tissue, researchers hope to uncover the exact mechanisms behind this damage and develop better ways to diagnose and potentially prevent it.
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If you qualify, you will have a small sample of heart tissue collected during a heart biopsy or transplant procedure that your doctor has already recommended for your care. Researchers will then study this tissue in the laboratory to analyze how your heart's mitochondria are functioning and how diabetes may have affected them. The study involves approximately 500 participants total, and your participation helps doctors better understand the link between diabetes and heart damage without requiring any additional procedures beyond what you're already having done.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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