Plain-English translation of NCT05965531 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a chemotherapy drug called (TAS-102) combined with radiation therapy to treat locally advanced rectal cancer. The study wants to see if this medication works well against the cancer while being gentler on patients than the chemotherapy drugs currently used. Researchers hope this approach will help patients manage their treatment better and have fewer troublesome side effects.
Current standard treatments for advanced rectal cancer use older chemotherapy drugs that can cause significant side effects — including painful hand and foot problems in up to 71% of patients. This medication has shown promise in treating other colorectal cancers with far fewer serious side effects, so researchers want to see if it works well for rectal cancer too.
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You would receive radiation therapy to your pelvis while also taking the medication by mouth, then undergo surgery if your doctors believe they can remove all the cancer. After surgery, you would receive additional chemotherapy cycles over several months. The entire treatment process would take several months, involving regular hospital or clinic visits for radiation, medication monitoring, surgical consultation, and follow-up care.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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