Plain-English translation of NCT05973799 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is investigating how fasting affects your body's natural ability to recover from dangerously low blood sugar (hypoglycemia) when you have type 1 diabetes. Researchers will compare your body's response to low blood sugar on two separate occasions: once after you've eaten breakfast and lunch, and once when you've been fasting. The goal is to understand whether fasting changes the hormones and processes your liver uses to bring your blood sugar back up.
People with type 1 diabetes often struggle with low blood sugar episodes that are hard to predict and control, and these episodes are a major barrier to safe diabetes management. Scientists have noticed in healthy people that fasting may change how the body responds during low blood sugar, and they want to know if this happens in people with type 1 diabetes too — information that could eventually help improve how low blood sugar is prevented or treated.
You likely qualify if…
You likely don't qualify if…
You will participate in two separate test visits. On one visit, you'll eat a regular breakfast and lunch, then receive insulin to intentionally lower your blood sugar under careful medical supervision while researchers monitor your body's response. On your second visit, you'll remain fasting before undergoing the same low blood sugar challenge. Throughout both visits, your blood will be tested to measure your body's natural recovery hormones and glucose production. The study involves about 10 participants total.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Sponsor
University of Cincinnati
Enrollment target
~10 participants
Started
October 2019
Primary completion
December 2024
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 45 Years
Last updated on clinicaltrials.gov in September 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jason Winnick, PhD
University of Cincinnati
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.