Plain-English translation of NCT05974449 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing Lactobacillus vaginalis capsules—a probiotic treatment—to help prevent uncomfortable vaginal symptoms in young women being treated for breast cancer. When you receive chemotherapy combined with ovarian protection medication, your estrogen levels drop significantly, which can cause vaginal dryness, irritation, itching, and pain during intercourse. This study wants to see whether the medication can help ease these symptoms and improve your quality of life during treatment.
Young breast cancer patients often experience bothersome vaginal symptoms as a side effect of their cancer treatment, but many feel too embarrassed to talk about them with their doctors. Current treatment options like vaginal estrogen may not be safe for breast cancer patients, so researchers are exploring whether this probiotic approach could be a gentler alternative.
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If you join this study, you will insert one capsule of the medication deep into your vagina each night for 10 days—starting on the day of your first or second chemotherapy cycle, and again during your third or fourth cycle. You will need to wash the area first, then insert the capsule before bed. The researchers will monitor your symptoms and vaginal health throughout your treatment to see whether the medication helps reduce discomfort.
AI-generated summary from trial data · Aug 11, 2026 · Not medical advice
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