Plain-English translation of NCT05975580 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
After bariatric surgery, some people regain weight over time. This study tests whether medications like or —either alone or combined—can help reverse that weight regain when paired with diet and lifestyle counseling. Everyone in the study will receive professional guidance on eating habits and lifestyle changes throughout the 12-month trial.
While bariatric surgery is very effective for severe obesity, many patients experience significant weight regain in the years after surgery. This trial aims to find out whether medication can help prevent or reverse that regain when combined with counseling support.
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You will be randomly assigned to take one of two medications or a placebo pill for the first 4 months, along with regular diet and lifestyle counseling from a dietitian. At the 4-month mark, if you have lost at least 5% of your weight, you'll continue the same treatment through month 12. If you haven't lost that much, you'll be switched to a higher dose or a different medication combination for the remaining 8 months. Throughout the entire year, you'll have regular visits to check your progress, discuss your eating habits, and receive support.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
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