Plain-English translation of NCT05976152 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Stroke research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial tests whether a medication called can help people who have experienced thinking or memory problems after a stroke. Some patients recover quickly after a stroke, but others develop lasting cognitive impairment—difficulty remembering, concentrating, or thinking clearly—that can affect their quality of life. This study will compare the medication to a placebo (a dummy pill) to see if this treatment can improve cognitive function and prevent these problems from getting worse.
After a stroke, between one-quarter and half of patients experience cognitive impairment, which increases their risk of disability and death. However, there are currently very few large, rigorous studies testing whether medications can prevent or treat these thinking and memory problems. This trial aims to fill that gap and find an effective treatment to help stroke survivors maintain their mental abilities.
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The study happens in two stages. In the first stage, you'll join shortly after your stroke and receive routine stroke care plus either the medication or a placebo daily for about 24 weeks, with regular follow-up visits for testing and brain imaging. In the second stage, if you develop thinking or memory problems during that period, you may continue in the treatment phase with ongoing cognitive assessments to measure whether the medication helps. You'll need to be able to attend appointments and complete memory and thinking tests throughout the study.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
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