Plain-English translation of NCT05976347 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
Many people develop depression after a serious bone fracture, and this depression can make their pain worse, delay healing, and lead to longer hospital stays. This study is testing whether treating depression early with medications like Fluoxetine or Duloxetine can help fracture patients recover better overall and feel less pain during their healing.
Most bone surgeons don't screen for or treat depression, even though depression is very common after traumatic fractures and makes recovery harder. This trial exists to see if treating depression with medication early on can lead to better pain control, fewer complications, and faster recovery for fracture patients.
You likely qualify if…
You likely don't qualify if…
You would take a daily antidepressant medication (either Fluoxetine or Duloxetine) as part of your regular fracture care, or you would be referred to a mental health professional with resources to help manage depression. Your doctors would monitor your depression symptoms and recovery outcomes over time as you heal from your fracture injury.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
Wake Forest University Health Sciences
Enrollment target
~100 participants
Started
June 2025
Primary completion
May 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Erica Grochowski, MPH
Wake Forest University Health Sciences
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.