Plain-English translation of NCT05977803 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
When lung cancer spreads to the brain, doctors use radiation therapy to treat these tumors. However, radiation can sometimes cause scar tissue damage in the brain months or years later, which looks similar to tumor growth on standard MRI scans. This study is testing a new MRI technique called CEST that doesn't require contrast dye injections and may be better at telling the difference between actual tumor return and radiation damage.
Current MRI scans have trouble reliably distinguishing between tumor regrowth and radiation scar tissue, which can lead to confusion about whether a patient needs more treatment. This new technique could help doctors make clearer decisions about your care without needing to inject contrast dye.
You likely qualify if…
You likely don't qualify if…
You would undergo a special MRI scan using the new CEST technique at Bichat Hospital's thoracic oncology department as part of your regular follow-up care for brain metastases. This is a diagnostic study, so you are not receiving new treatment—instead, researchers are testing whether this imaging method can better identify radiation damage versus tumor growth. The scan itself is non-invasive and does not require contrast dye injection.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
France
Sponsor
Assistance Publique - Hôpitaux de Paris
Enrollment target
~60 participants
Started
February 2024
Primary completion
February 2029
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Augustin Gaudemer, MD
Assistance Publique - Hôpitaux de Paris
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.