Plain-English translation of NCT05977907 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This clinical trial is testing whether it's safe to give people with head and neck cancer a combination of two medications— and —before their surgery to remove the tumor. The study wants to see if these immune-boosting drugs can help the body fight cancer more effectively and if they can be safely given before surgery without causing serious side effects or delaying the operation.
Current treatments for head and neck cancer may not work well enough for all patients. Researchers believe that preparing the immune system to fight cancer before surgery might improve outcomes and help prevent cancer from coming back.
If you join this study, you will receive one intravenous infusion of , followed by six weekly injections of the second medication before your scheduled surgery. After surgery, you will continue receiving both medications on an extended schedule over several months— infusions every 6 weeks for 8 doses, and additional injections of the second medication. Throughout the study, you'll have regular visits to monitor for side effects, blood tests to check organ function, and tumor biopsies before treatment begins and during your care.
AI-generated summary from trial data · Oct 3, 2026 · Not medical advice
United States