Plain-English translation of NCT05982158 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial compares two types of therapy for people who persistently hear critical, abusive, or threatening voices—a symptom that affects many people with schizophrenia and related disorders. One group will receive standard cognitive behavioral therapy (CBT), which is the current best practice. The other group will try avatar therapy, a newer approach where a therapist creates a virtual character that represents the voice you hear, allowing you to practice new ways of responding to it in a safe, controlled setting.
Current treatments for persistent hearing voices have only modest success, leaving many people still struggling despite taking antipsychotic medication. Early research suggests this new virtual avatar approach may produce some of the largest improvements in voice symptoms seen to date, so this trial is testing whether it genuinely works better than standard therapy.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will be randomly assigned to receive either standard cognitive behavioral therapy or avatar therapy, delivered remotely via video sessions. In CBT, you'll work with a therapist to understand your voices and learn coping strategies. In avatar therapy, you'll work with a therapist to create a virtual character that represents your primary voice, then practice responding to it differently. The trial involves about 212 participants total, and sessions will take place over several weeks.
AI-generated summary from trial data · Jun 26, 2026 · Not medical advice
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