Plain-English translation of NCT05983211 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called continuous theta-burst repetitive transcranial magnetic stimulation (cTBS) — a non-invasive way to stimulate specific areas of the brain using magnetic pulses — in people with ALS. Researchers want to see if this treatment is safe and whether it can help reduce the overactivity in motor brain cells that happens in ALS, potentially slowing symptom progression.
ALS causes nerve cells to die, leading to muscle weakness and paralysis. In ALS, certain motor brain cells become overactive in a way that may speed up this damage. This trial aims to find out if the new treatment can calm this overactivity and help protect remaining nerve cells.
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You would receive intensive magnetic brain stimulation over 5 consecutive days, with up to 8 treatment sessions per day (each lasting 40 seconds to 4 minutes). After the initial week, you would return for single maintenance sessions every 2 weeks for 12 weeks, then every 4 weeks for another 12 weeks. Throughout the study, you would have brain imaging scans, blood tests, and muscle strength measurements to track any changes over the 24-week period.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
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