Plain-English translation of NCT05985161 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a medication called to see if it can treat children whose solid tumors have returned or stopped responding to standard chemotherapy. works by targeting a specific protein that helps cancer cells survive. The study will enroll children ages 12 months and older with Wilms tumors (kidney cancer), rhabdoid tumors, nerve tumors called MPNST, or other solid cancers that may respond to this treatment.
Children with relapsed or treatment-resistant solid tumors have limited options, and standard chemotherapy is not working for them. This medication targets a different pathway in cancer cells, offering hope for children who have exhausted other treatments.
You likely qualify if…
You likely don't qualify if…
You would take as an oral medication (by mouth) and visit the study center regularly so doctors can monitor how well the treatment is working and manage any side effects. The study is divided into groups based on tumor type, so your specific plan will depend on your diagnosis. You'll have blood tests, imaging scans, and physical exams to track your response to the medication throughout the study.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States