Testing a new pill for advanced solid cancers

Plain-English translation of NCT05985655 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing a new experimental medication called in people with advanced solid cancers that have not been controlled by standard treatments. Researchers want to understand how safe this medication is, how the body processes it, and whether it can help shrink or slow down tumors. The study will test the medication alone and also combined with standard cancer treatments.

Many people with advanced cancers—including lung, breast, ovarian, pancreatic, and head and neck cancers—run out of effective treatment options. This trial is exploring whether this new medication could offer a new path forward for patients whose cancers have stopped responding to other therapies.

Do you qualify?

You likely qualify if…

you have been diagnosed with an advanced solid tumor (such as lung cancer, breast cancer, ovarian cancer, pancreatic cancer, or head and neck cancer) that cannot be cured by surgery or radiation alone
your cancer has progressed despite prior standard treatments
you are healthy enough to tolerate treatment, with a good performance status and life expectancy of at least 3 months
you have adequate liver, kidney, and blood cell function
you have a tumor that can be safely biopsied (a small tissue sample can be taken for testing)

You likely don't qualify if…

you have an active, serious infection at the time of enrollment
you have cancer that has spread to your brain and is causing symptoms
you have severe nausea, vomiting, or digestive problems that would prevent you from absorbing the pill properly
you have a serious heart condition or have had an organ transplant
you have received chemotherapy or radiation within the past 4 weeks, or are taking medications that would interfere with how your body processes this treatment

What participation looks like

The study has two phases. In Phase 1, researchers will gradually increase the dose of the medication to find the safest and most effective dose, testing it alone or combined with standard cancer treatments. In Phase 2, participants with specific cancer types will receive the medication at the dose determined to work best. You will take the medication by mouth as tablets and visit the clinic regularly for blood tests, imaging scans, and check-ups to monitor how well the treatment is working and watch for side effects.

AI-generated summary from trial data · Aug 17, 2026 · Not medical advice

Trial locations(15 sites)

United States

USC Norris Comprehensive Cancer Center, Los Angeles, California

START Midwest, Grand Rapids, Michigan

Memorial Sloan Kettering Cancer Center, New York, New York

The Ohio State University, Columbus, Ohio

START San Antonio, San Antonio, Texas