Testing a new pill for advanced cancers in multiple types

Plain-English translation of NCT05985655 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated July 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing a new experimental medication called to see if it can help treat advanced solid cancers that have spread or come back after standard treatment. Researchers want to find the right dose and understand how well this medication works, either by itself or combined with treatments you may already be receiving. The study will enroll about 230 people across multiple cancer types.

Many advanced cancers stop responding to current treatments, and patients need new options. This medication was designed using artificial intelligence to target cancer cells in a new way, and early testing suggests it may help—so researchers want to test it safely in patients to see if it truly works.

Do you qualify?

You likely qualify if…

you have been diagnosed with one of these advanced cancers: head and neck, pancreatic, lung, breast (certain types), or ovarian/peritoneal/fallopian tube cancer
your cancer has spread, come back, or cannot be treated with surgery or radiation alone
you are in good enough overall health to tolerate the treatment (your doctor will assess this)
you have a life expectancy of at least 3 months
your liver, kidney, and blood cell counts are working well enough to handle the medication

You likely don't qualify if…

you have an active, serious infection
you have cancer that has spread to your brain and is causing symptoms
you have severe nausea, vomiting, or digestive problems that would prevent you from absorbing the pill
you have had a major organ transplant or stem cell transplant
you have received other cancer treatments within the past 4 weeks or are taking certain medications that interfere with how this drug works

What participation looks like

You will take the experimental medication by mouth as a pill, either alone or combined with a standard cancer treatment your doctor recommends. The study starts by testing lower doses and gradually increases them to find the safest, most effective dose—your dose may be adjusted based on how you respond. You will have regular visits with your study team for blood work, scans, and biopsies to check how your tumor responds and monitor for side effects.

AI-generated summary from trial data · Jul 6, 2026 · Not medical advice

Trial locations(13 sites)

United States

USC Norris Comprehensive Cancer Center, Los Angeles, California

START Midwest, Grand Rapids, Michigan

START San Antonio, San Antonio, Texas

START Mountain Region, West Valley City, Utah

Belgium

GZA Ziekenhuizen - Campus Sint-Augustinus, Antwerp