Plain-English translation of NCT05985785 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether injecting concentrated cells from your own bone marrow into your knee works better than a steroid injection for relieving arthritis pain. Both treatments involve an injection into the affected knee, and researchers will track your pain and function for up to six months to compare how well each one works.
Many people with knee arthritis don't get enough pain relief from standard treatments like physical therapy, weight loss, and anti-inflammatory drugs. This trial is exploring whether using your own bone marrow cells—which contain healing compounds—might provide longer-lasting relief than steroid injections alone.
You likely qualify if…
You likely don't qualify if…
If you enroll, you will be randomly assigned to receive either a bone marrow cell injection or a steroid injection into your knee. The bone marrow group will have bone marrow drawn from your body, processed in a laboratory, and then injected back into your knee. The steroid group will receive a steroid injection with a small sham (fake) incision to match the experience. You will then be followed for six months with visits and questionnaires to track your pain levels and how well you're functioning.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States
Sponsor
Rush University Medical Center
Enrollment target
~100 participants
Started
July 2022
Primary completion
December 2027
Age range
18 Years – 70 Years
Last updated on clinicaltrials.gov in August 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Carla M. Edwards, PhD
Rush University Medical Center Associate Professor and Surgeon
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.