Plain-English translation of NCT05985954 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new drug called combined with one or two standard colorectal cancer medications (, and possibly ) for people whose cancer has spread and no longer responds to previous treatments. The study will determine the safest and most effective dose of this medication when used with these existing drugs, and whether it can help slow or shrink the cancer.
Colorectal cancer that has spread to other parts of the body and stops responding to standard treatments is very difficult to manage. Researchers believe that combining this new medication with existing drugs might work better by targeting cancer cells in a new way.
You likely qualify if…
You likely don't qualify if…
You would take the study medication by mouth, combined with intravenous infusions of standard cancer drugs, over several treatment cycles. You would need to visit the hospital or clinic regularly for blood tests, scans to measure your tumor, and monitoring for side effects. The study will test different doses of the medication to find the safest and most effective combination, and researchers will take blood samples to understand how the treatment is working in your body.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
United States