Plain-English translation of NCT05988463 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Phase 1 โ Testing in a small group (usually 20โ80 people) to find a safe dose and watch for side effects.
This trial is testing a medication called artesunate to see if it is safe and how well patients tolerate it when treating idiopathic pulmonary fibrosis (IPF) โ a disease in which lung tissue becomes scarred, making it harder to breathe. Researchers will gradually increase doses of the medication over 12 weeks while carefully monitoring how your body responds. Half of participants will receive the medication and half will receive a placebo (a pill with no active ingredient) to help doctors understand whether any benefits come from the treatment itself.
IPF is a serious, progressive disease with limited treatment options. Current medications slow the disease but don't stop it. Researchers want to explore whether this medication could help by reducing lung scarring and improving how the lungs work.
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You will visit the research center multiple times over 20 weeks. After an initial 4-week screening period, you will take the study medication (or placebo) by mouth for 12 weeks, with the dose increasing every 4 weeks. During this time, you will have blood tests, breathing tests, and questionnaires about your symptoms. Then you will have a 4-week follow-up period where researchers continue to monitor how you are doing. Throughout the study, your safety and how well you tolerate the medication are the main focus.
AI-generated summary from trial data ยท Jun 26, 2026 ยท Not medical advice
United States