Plain-English translation of NCT05992259 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial tested auricular vagus nerve stimulation—a gentle, non-invasive treatment applied to the ear—to see if it could reduce damage to the heart muscle after a heart attack. Researchers studied whether stimulating the vagus nerve during emergency heart procedures could help the heart recover better and prevent complications from the treatment itself.
When doctors restore blood flow to a blocked heart artery during a heart attack, the sudden return of blood can actually cause additional damage to the heart muscle, known as reperfusion injury. This trial was designed to test whether this new treatment could reduce that damage and improve outcomes for heart attack patients.
Participants received either active vagus nerve stimulation or a placebo treatment applied to their ear during their emergency heart procedure. Half of the patients received the active treatment on the inner ear (tragus), while the other half received the sham treatment on the earlobe, and the study followed their heart function and recovery afterward.
AI-generated summary from trial data · Aug 2, 2026 · Not medical advice
Russia
Collaborators
State Budget Public Health Institution Scientific Research Institute - Ochapovsky Regional Clinical Hospital
Enrollment target
~110 participants
Started
September 2022
Primary completion
March 2026
Age range
40 Years – 75 Years
Last updated on clinicaltrials.gov in July 2026.