Plain-English translation of NCT05995496 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers are studying how the brain controls impulses and makes decisions in people with bulimia nervosa—an eating disorder involving cycles of binge eating and purging. This study uses brain imaging (called fMRI) combined with computer modeling to understand how eating and fasting affect the brain's control systems. The goal is to develop better ways to predict and treat bulimia nervosa by understanding the brain changes that happen during these cycles.
Current treatments for bulimia nervosa don't work well for everyone, partly because doctors don't fully understand the brain mechanisms driving the disorder. This research aims to fill that gap by mapping exactly how hunger and eating change the brain's ability to control impulses and make good decisions.
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You will visit the research center twice, about a week apart. On one visit, you'll come after fasting for 16 hours (nothing to eat, only water). On the other visit, you'll come after eating a standard meal. During each visit, you'll complete brain imaging scans while doing some decision-making tasks on a computer. Each scan takes about an hour. The researchers will also ask you questions about your eating habits and mood using your phone between visits.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
United States
Sponsor
Icahn School of Medicine at Mount Sinai
Collaborators
National Institute of Mental Health (NIMH)
Enrollment target
~150 participants
Started
December 2023
Primary completion
December 2027
Age range
18 Years – 45 Years
Sex
Female only
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Riley Macks, B.A.
Mount Sinai Icahn School of Medicine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.