Plain-English translation of NCT05995951 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing deep brain stimulation (DBS) surgery as a treatment for severe obsessive-compulsive disorder (OCD) in people whose symptoms have not improved with standard medications and therapy. DBS involves implanting a small device in the brain that sends electrical signals to help reduce OCD symptoms. Research over the past decade suggests that this treatment can help about half of patients with very severe OCD reduce their symptoms significantly.
About 1 in 10 people with OCD don't improve even after trying the best available medications and psychological treatment, leaving them severely affected in their daily life. This trial exists to see whether the treatment can safely and effectively help these patients when nothing else has worked.
You likely qualify if…
You likely don't qualify if…
The trial has two parts. First, two participants will receive the DBS surgery openly. Then, eight more participants will have surgery followed by a randomized phase: some will receive active stimulation for four months while others receive sham (inactive) stimulation, then the groups will switch for another four months. Before surgery, you'll have psychiatric and neurosurgical evaluations. The actual surgery involves implanting electrodes and a small device in your brain. You'll visit the clinic regularly so doctors can monitor your symptoms and adjust the device if needed.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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