Plain-English translation of NCT05996016 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is asking women living with HIV to participate in a long-term observation to help doctors understand why some women develop cervical problems more easily than others. The study focuses on how the natural bacteria in the vagina—called the microbiota—might influence whether women get infected with HPV (a common virus) and develop cervical lesions or precancerous changes. By collecting information and samples from 400 women, researchers hope to discover the connection between these bacteria and cervical disease so they can develop better prevention strategies.
Women living with HIV face a higher risk of HPV infection and serious cervical disease, but doctors don't yet fully understand why. This study aims to fill that gap by investigating whether an imbalance in vaginal bacteria makes these women more vulnerable to HPV and cervical problems—knowledge that could lead to new ways to protect women's health.
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As a participant, you would be part of an observational study—meaning researchers will monitor your health over time rather than ask you to take a new medication. You would likely have regular clinic visits where doctors collect information about your health history, perform cervical exams, and take samples (such as vaginal swabs) to analyze your bacteria. The study involves no experimental treatment, just careful tracking and testing to help researchers understand the patterns they're investigating.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
China
Sponsor
Peking Union Medical College Hospital
Enrollment target
~400 participants
Started
January 2017
Primary completion
January 2029
Age range
14 Years and older
Sex
Female only
Last updated on clinicaltrials.gov in December 2025.
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Central contact
Wei Lyu, MD
No. 10Yi，Chaowai Street ，Chaoyang District ，Beijing ，China
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