Plain-English translation of NCT05996900 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is investigating how repetitive transcranial magnetic stimulation (rTMS) — a noninvasive treatment that uses magnetic pulses to stimulate the brain — actually works in people with depression. Researchers want to understand the brain changes that happen during a single treatment session and across multiple sessions, and whether computer models can predict which patients will benefit most. By understanding these mechanisms better, scientists hope to improve the treatment for the many patients who don't fully respond to current rTMS therapy.
While this treatment is approved and helps some people with depression, only 20–40% of patients go into remission, and doctors don't yet understand which patients will respond or how to optimize the treatment. This study aims to fill that gap by measuring exactly what happens in the brain during therapy, which could lead to better outcomes for future patients.
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As a participant, you would receive brain stimulation through either magnetic pulses applied to your scalp or through electrodes directly on your brain during your routine clinical monitoring. Researchers would simultaneously record your brain's electrical activity using various monitoring methods to see how your brain responds to the stimulation. The study involves multiple sessions of this stimulation and monitoring, with some participants receiving real stimulation and others receiving sham (placebo) stimulation for comparison purposes.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
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