Plain-English translation of NCT06006884 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers at Mayo Clinic want to understand why some people who had severe COVID-19 develop long-term lung problems while others recover completely. This study will follow two groups of people—those who were hospitalized with severe COVID-19 and those who had mild COVID-19—over 12 months, collecting blood samples, lung samples through a breathing tube procedure, and imaging tests to identify what biological changes might explain lasting lung issues.
Many people who survived severe COVID-19 continue to struggle with breathing problems and reduced lung function months or years later, but doctors don't yet understand why this happens to some people and not others. This research aims to identify the biological mechanisms driving these chronic lung problems so that better treatments can be developed.
You likely qualify if…
You likely don't qualify if…
You will visit Mayo Clinic three times over 12 months—first around 2–3 months after your COVID-19 diagnosis, again at 6 months, and finally at 12 months. At each visit, you'll have lung imaging (CT scans), breathing tests, blood draws, and complete questionnaires about your symptoms and quality of life. At your first and final visits, doctors will also perform a bronchoscopy—a procedure where a thin tube is passed down your airway to collect fluid samples from your lungs—to study immune and molecular changes.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Enrollment target
~67 participants
Started
January 2024
Primary completion
August 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2026.
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.