Plain-English translation of NCT06009276 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are studying how the bacteria naturally living in your mouth might play a role in heart and blood vessel health. They're interested in whether these bacteria affect how well blood flows to your muscles during exercise, especially in people with heart failure or peripheral artery disease. The study will also test whether concentrated beetroot juice—which contains compounds that may improve blood flow—could help improve these outcomes.
Heart disease is the leading cause of death in America, and scientists have discovered that a key chemical called nitric oxide helps protect blood vessels and improve blood flow. Your mouth bacteria may play an important role in creating this protective chemical, but we don't yet understand how well this process works in people with heart disease compared to healthy people. This study aims to fill that gap so doctors can eventually develop better treatments.
You likely qualify if…
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If you join this study, you'll provide samples from your mouth (tongue swabs, saliva) so researchers can analyze your bacteria. You'll also have blood drawn, undergo vascular testing (ultrasound imaging of your blood vessels), and complete a maximal exercise test to measure your fitness. If you're interested, you can optionally participate in a supplementation assessment where you'd try concentrated beetroot juice. The study is based at the University of Virginia and is currently recruiting participants.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
United States
Sponsor
University of Virginia
Enrollment target
~70 participants
Started
August 2023
Primary completion
December 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in December 2025.
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Central contact
Casey C Derella, PhD
University of Virginia
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.